Previous publications from Michael Birnbaum’s prior lab work can be found below.
Fernandes, R. A., Li, C., Wang, G., Yang, X., Savvides, C. S., Glassman, C. R., Dong, S., Luxenberg, E., Sibener, L. V., Birnbaum, M. E., Benoist, C., Mathis, D., & Garcia, K. C. (2020). Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo. eLife, 9.
DOI: https://doi.org/10.7554/elife.58463
Mendoza, J. L., Fischer, S., Gee, M. H., Lam, L. H., Brackenridge, S., Powrie, F. M., Birnbaum, M., McMichael, A. J., Garcia, K. C., & Gillespie, G. M. (2020). Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity. eLife, 9.
DOI: https://doi.org/10.7554/elife.58128
Gee, M. H., Sibener, L. V., Birnbaum, M. E., Jude, K. M., Yang, X., Fernandes, R. A., Mendoza, J. L., Glassman, C. R., & Garcia, K. C. (2018). Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide Velcro. Proceedings of the National Academy of Sciences, 115(31).
DOI: https://doi.org/10.1073/pnas.1802746115
Sibener, L. V., Fernandes, R. A., Kolawole, E. M., Carbone, C. B., Liu, F., McAffee, D., Birnbaum, M. E., Yang, X., Su, L. F., Yu, W., Dong, S., Gee, M. H., Jude, K. M., Davis, M. M., Groves, J. T., Goddard, W. A., Heath, J. R., Evavold, B. D., Vale, R. D., & Garcia, K. C. (2018). Isolation of a structural mechanism for uncoupling T cell receptor signaling from peptide-MHC binding. Cell, 174(3).
DOI: https://doi.org/10.1016/j.cell.2018.06.017
Gee, M. H., Han, A., Lofgren, S. M., Beausang, J. F., Mendoza, J. L., Birnbaum, M. E., Bethune, M. T., Fischer, S., Yang, X., Gomez-Eerland, R., Bingham, D. B., Sibener, L. V., Fernandes, R. A., Velasco, A., Baltimore, D., Schumacher, T. N., Khatri, P., Quake, S. R., Davis, M. M., & Garcia, K. C. (2018). Antigen identification for orphan T cell receptors expressed on tumor-infiltrating lymphocytes. Cell, 172(3).
DOI: https://doi.org/10.1016/j.cell.2017.11.043
Hilton, H. G., McMurtrey, C. P., Han, A. S., Djaoud, Z., Guethlein, L. A., Blokhuis, J. H., Pugh, J. L., Goyos, A., Horowitz, A., Buchli, R., Jackson, K. W., Bardet, W., Bushnell, D. A., Robinson, P. J., Mendoza, J. L., Birnbaum, M. E., Nielsen, M., Garcia, K. C., Hildebrand, W. H., & Parham, P. (2017). The intergenic recombinant HLA-B∗46:01 has a distinctive peptidome that includes KIR2DL3 ligands. Cell Reports, 19(7), 1394–1405.
DOI: https://doi.org/10.1016/j.celrep.2017.04.059
Adams, J. J., Narayanan, S., Birnbaum, M. E., Sidhu, S. S., Blevins, S. J., Gee, M. H., Sibener, L. V., Baker, B. M., Kranz, D. M., & Garcia, K. C. (2015). Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity. Nature Immunology, 17(1), 87–94.
DOI: https://doi.org/10.1038/ni.3310
Carrillo, R. A., Özkan, E., Menon, K. P., Nagarkar-Jaiswal, S., Lee, P.-T., Jeon, M., Birnbaum, M. E., Bellen, H. J., Garcia, K. C., & Zinn, K. (2015). Control of synaptic connectivity by a network of Drosophila IgSF cell surface proteins. Cell, 163(7), 1770–1782.
DOI: https://doi.org/10.1016/j.cell.2015.11.022
Secor, P. R., Sweere, J. M., Michaels, L. A., Malkovskiy, A. V., Lazzareschi, D., Katznelson, E., Rajadas, J., Birnbaum, M. E., Arrigoni, A., Braun, K. R., Evanko, S. P., Stevens, D. A., Kaminsky, W., Singh, P. K., Parks, W. C., & Bollyky, P. L. (2015). Filamentous bacteriophage promote biofilm assembly and function. Cell Host & Microbe, 18(5), 549–559.
DOI: https://doi.org/10.1016/j.chom.2015.10.013
Yu, W., Jiang, N., Ebert, P. J. R., Kidd, B. A., Müller, S., Lund, P. J., Juang, J., Adachi, K., Tse, T., Birnbaum, M. E., Newell, E. W., Wilson, D. M., Grotenbreg, G. M., Valitutti, S., Quake, S. R., & Davis, M. M. (2015). Clonal deletion prunes but does not eliminate self-specific αβ CD8+ T lymphocytes. Immunity, 42(5), 929–941.
DOI: https://doi.org/10.1016/j.immuni.2015.05.001
Birnbaum, M. E., & Garcia, K. C. (2015). Self-determination in the T cell repertoire. Immunity, 42(1), 8–10.
DOI: https://doi.org/10.1016/j.immuni.2014.12.025
Birnbaum, M. E., Berry, R., Hsiao, Y.-S., Chen, Z., Shingu-Vazquez, M. A., Yu, X., Waghray, D., Fischer, S., McCluskey, J., Rossjohn, J., Walz, T., & Garcia, K. C. (2014). Molecular architecture of the αβ T cell receptor–CD3 complex. Proceedings of the National Academy of Sciences, 111(49), 17576–17581.
DOI: https://doi.org/10.1073/pnas.1420936111
Birnbaum, M. E., Mendoza, J. L., Sethi, D. K., Dong, S., Glanville, J., Dobbins, J., Özkan, E., Davis, M. M., Wucherpfennig, K. W., & Garcia, K. C. (2014). Deconstructing the peptide-MHC specificity of T cell recognition. Cell, 157(5), 1073–1087. https://doi.org/10.1016/j.cell.2014.03.047
DOI: https://doi.org/10.1016/j.cell.2014.03.047
Kim, T., Vidal, G. S., Djurisic, M., William, C. M., Birnbaum, M. E., Garcia, K. C., Hyman, B. T., & Shatz, C. J. (2013). Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer’s model. Science, 341(6152), 1399–1404.
DOI: https://doi.org/10.1126/science.1242077
Birnbaum, M. E., Dong, S., & Garcia, K. C. (2012). Diversity‐oriented approaches for interrogating T‐cell receptor repertoire, ligand recognition, and function. Immunological Reviews, 250(1), 82–101.
DOI: https://doi.org/10.1111/imr.12006
Garcia, K. C., Gapin, L., Adams, J. J., Birnbaum, M. E., Scott-Browne, J. P., Kappler, J. W., & Marrack, P. (2012). A closer look at TCR Germline Recognition. Immunity, 36(6), 887–888.
DOI: https://doi.org/10.1016/j.immuni.2012.05.018
Adams, J. J., Narayanan, S., Liu, B., Birnbaum, M. E., Kruse, A. C., Bowerman, N. A., Chen, W., Levin, A. M., Connolly, J. M., Zhu, C., Kranz, D. M., & Garcia, K. C. (2011). T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity, 35(5), 681–693.
DOI: https://doi.org/10.1016/j.immuni.2011.09.013
Lupardus, P. J., Birnbaum, M. E., & Garcia, K. C. (2010). Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Rα2. Structure, 18(3), 332–342.
DOI: https://doi.org/10.1016/j.str.2010.01.003
Brudno, Y., Birnbaum, M. E., Kleiner, R. E., & Liu, D. R. (2009). An in vitro translation, selection and amplification system for peptide nucleic acids. Nature Chemical Biology, 6(2), 148–155.
DOI: https://doi.org/10.1038/nchembio.280
Kleiner, R. E., Brudno, Y., Birnbaum, M. E., & Liu, D. R. (2008). DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes. Journal of the American Chemical Society, 130(14), 4646–4659.
DOI: https://doi.org/10.1021/ja0753997